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Tramadol: Your Weapon Against Chronic Pain

If you have a condition that affects your breathing (such as a blockage or narrowing of the stomach or intestines) or a history of seizures, this medication may not be safe for you. It is also not recommended for use during pregnancy because it could harm the unborn baby.

Your doctor will monitor your breathing rate carefully when you first start taking tramadol and after any increases in dosage. They will also test your kidney function to make sure it’s working well.

1. It’s Non-Opioid

Tramadol is a non-opioid drug that binds to opioid receptors in the brain and spinal cord to relieve pain. It belongs to a group of medicines called opioid analgesics, but it doesn’t act like most other opioids and has much less potency. It is considered a Step 2 option on the World Health Organization’s pain ladder, meaning it relieves moderate to severe pain with few side effects and has low risk of addiction compared to other opioids.

Tramal is a centrally acting synthetic opioid analgesic and SNRI, demonstrating high efficacy against both nociceptive pain (such as headache or abdominal pain) and neuropathic pain conditions (such as autoimmune demyelinating disorders, chronic inflammatory arthritis, spinal cord injury-related neuropathic pain, neuropathic neuropathy of sickle cell disease and CRPS). Tramal is also highly effective for treating muscle spasms associated with MS.

The most common side effect of tramadol is nausea or vomiting, but it can cause drowsiness and dizziness as well. Tramadol can interact with certain medicines, including antidepressants, NSAIDs and MAO inhibitors. Talk to your doctor before taking tramadol with any of these medications or if you have other health problems, such as liver or kidney disease, asthma or breathing problems, stomach or intestinal blockage, or a history of seizures.

Taking too much of this medicine can lead to an overdose, which has serious and sometimes life-threatening symptoms. Overdose symptoms include not responding to sound or touch, extreme drowsiness, slow or shallow breathing, and cold or clammy skin. Carry naloxone (Narcan, Zimhi) with you in case of an overdose.

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2. It’s Non-Addictive

Tramadol does not affect the opioid receptors in the brain and spinal cord that change the way your body perceives pain. This makes it less prone to addiction than other opioid medications like oxycodone or hydrocodone. However, tramadol is still a schedule IV drug in the US, meaning it can cause dependence and withdrawal symptoms when used for extended periods of time.

It also can interact with other drugs and may have severe side effects if combined with certain other medicines such as sedatives, antidepressants, narcotic pain relievers, or MAO inhibitors (isocarboxazid, linezolid, methylene blue injection, rasagiline, selegiline, tranylcypromine). This combination can increase your risk of seizures and life-threatening slowed breathing. Tramadol can also interact with alcohol, so you should avoid it if possible.

You should be aware of the signs of an overdose, which include unresponsiveness to sound or touch, very slowed breathing, cold skin, or clammy skin. If you suspect an overdose, seek emergency medical help immediately. Your doctor may prescribe naloxone, which is an antidote to opioid overdoses. Keep it on hand at all times and make sure that anyone who cares for you knows where it is and how to use it. If naloxone is not available, call 911 and perform CPR until emergency responders arrive.

3. It’s Safe

Tramadol is a centrally acting synthetic opioid analgesic with less risk of gastrointestinal complications, organ damage and respiratory distress than many other opioids. It is considered a Step 2 option on the World Health Organization’s pain ladder and is about 1/10th as potent as morphine. This is why it is a safer option for chronic pain.

Your doctor may check your blood pressure and kidney function before starting this medication. They’ll also monitor you closely if you take it for a long time or increase the dose. They’ll probably also want to test your liver function at regular intervals.

You should talk to your doctor before you have surgery while on this medication. It can also raise your chances of seizures. If you have a history of seizures or head injury, your doctor might not recommend tramadol. It can also affect the pressure in your brain. This can worsen certain types of headaches and make it harder for doctors to diagnose and treat your headaches.

4. It’s Effective

Despite its risk of addiction and dependence, the opioid pain medication Tramadol has been found to be effective at relieving chronic pain. It works by attaching to opioid receptors in your brain and spinal cord to block pain signals from reaching your brain.

Like all medications, tramadol has some side effects. But the majority of these are mild and should go away as your body gets used to the medicine. Some of these include nausea, stomach upset, vomiting, tiredness, dizziness, drowsiness, constipation and dry mouth. In rare cases, tramadol can increase the amount of pressure inside your head (intracranial hypertension), which could lead to life-threatening breathing problems. If you have a head injury or a condition that increases the pressure in your brain, talk to your doctor before taking tramadol.

Tramadol may interact with certain drugs that can raise your risk of serious or life-threatening breathing problems, such as sedatives, antidepressants, narcotics and other medicines for pain or anxiety; alcohol; a lung disease called chronic obstructive pulmonary disease (COPD); or seizure disorders. It also can make certain stomach or bowel conditions worse, such as ulcers; gall bladder problems; pancreas, liver or thyroid diseases; and low levels of sodium in your blood (hyponatremia).

As a controlled substance, tramadol has the potential to cause dependence and abuse, so you should use it for only as long as needed and at a dose that is safe for you. Your doctor will discuss these risks with you and explain how to store and dispose of the drug properly.

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